technische universität braunschweig institut für mikrobiologie

Start. 10.06.2010 Rainer Renkawitz 24.06.2010 Thomas Schirrmann, Technische Universität Braunschweig Generation of human antibodies and antibody fusion proteins for research, diagnostics and therapy 17.06.2010 Volker Wissemann; Institut für Botanik, Universität Gießen Host-parasite interaction in a case study of hybridogenic polyploids. This work was funded by the German Bundesministerium für Bildung und Forschung (BMBF) for the National Genome Research Network (NGFN2-EP, grant no. Teaching Winter Semester 2020/2021; CS department TU Braunschweig Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany Search for more papers by this author Jeroen S. Dickschat We have chosen the Gram negative proteobacterium Pseudomonas aeruginosa. First, the external databases KEGG (9), PGDv2 (16), ENZYME (17), BioCyc (5) provide EC numbers for the proteins. Upon registration you will receive an e-mail for confirmation. Despite this importance, the molecular mechanisms mediating this process are only poorly understood in biological systems. 1 Türk-Alman Üniversitesi, Fen Fakültesi, Istanbul, Turkey Technische Universität Braunschweig, Institut für Mikrobiologie, Braunschweig, Germany Social Media Facebook; Twitter; YouTube; Instagram; Kontakt. * strain absent in KEGG (version 13th April 2006). Dishi Liu | Braunschweig und Umgebung, Deutschland | Researcher bei Technische Universität Braunschweig, Institut für Wissenschaftliches Rechnen | 53 Kontakte | Vollständiges Profil von Dishi auf LinkedIn anzeigen und vernetzen Thank you for submitting a comment on this article. Juni wurde er zum Professor ernannt. 0313398A), BMBF for the Bioinformatics Competence Center Intergenomics (Grant No. The novel betacoranavirus SARS-CoV-2 causes a form of severe pneumonia disease, termed COVID-19 (coronavirus disease 2019). Here we focus on data integration for the biotechnologically and medically relevant group of bacteria, the pseudomonads. The novel betacoranavirus SARS-CoV-2 causes a form of severe pneumonia disease, termed COVID-19 (coronavirus disease 2019). Recombinant human antibodies are proven potent neutralizers of viruses and can block the interaction of viral surface proteins with their host receptors. Ovarian cancer risk score predicts chemo-response and outcome in epithelial ovarian carcinoma patients. Dear students and all interested parties, we are re-designing our website and want to include you in the process. The corresponding annotation process is described in the following sections. Institut für Technische Mikrobiologie. Intern BMW Manufacturing Co., LLC März 2020 – Sept. 2020 7 Monate. (3)Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstrasse 7, Braunschweig 38106, Germany Helmholtz Centre for Infection Research, Braunschweig 38124, Germany. Sehen Sie, wen Institut für Klinische Radiologie, Klinikum der Universität München, Munich, Germany für diese Position eingestellt hat. Technische Universität Braunschweig, Helmholtz-Zentrum für Infektionsforschung. Search for more papers by this author. Reconstruction of metabolic networks in SYSTOMONAS was achieved via comparative genomics. Region: Global Subject/journal group: All. Please check for further notifications by email. Interaction of Streptococcus pneumoniae with the surface of endothelial cells is mediated in blood flow via mechanosensitive proteins such as the Von Willebrand Factor (VWF). The homologous protein pairs can be obtained from the SYSTOMONAS protein table and visualized as multiple alignments, which are produced by MUSCLE [MUltiple Sequence Comparison by Log-Expectation (20)]. Our database comprises information on eight different Pseudomonas species and strains, which genomes have been completely sequenced and functionally annotated. Genes and proteins of eight Pseudomonas species and strains are carefully annotated by the Pseudomonas community and involved genome projects (16). Zur anonymisierten Webanalyse nutzt die TU Braunschweig die Software Matomo. Both viruses use the human ACE2 receptor for cell entry, recognizing it with the Receptor Binding Domain (RBD) of the S1 subunit of the viral spike (S) protein. The S2 domain mediates viral fusion with the host … Conflict of interest statement. Moreover, 11 exemplary protein spots from one proteome experiment were entered. For a start, we included our own experimental data obtained for the P.aeruginosa strain PAO1 measured under different growth conditions. We need your help to improve our website! (4)Institut für Mikrobiologie, Technische Universität Braunschweig; Bis 2020, Technologie Management, Technische Universität Braunschweig. The database is accessible at Author Webpage. Technische Universität Braunschweig stands for a strategic and achievement-oriented way of thinking and acting, dedicated teaching, multi-layered networking with our partners in science, industry and society, and intensive international cooperation projects. SYSTOMONAS architecture: combining the data warehouse concept and web services to provide a quick and dynamically updated data integration. Global optimization via the dual SONC cone and linear programming. Corresponding Author. Several other databases, such as Atlas (26) are organized as data warehouses. Es werden keine Bewerbungen mehr angenommen. With this database we would like to encourage the Pseudomonas community to elucidate cellular processes of interest using an integrated systems biology strategy. Cell-to-cell fusion is crucial for the development and propagation of most eukaryotic organisms. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Besides our own experimental metabolome, proteome and transcriptome data, various additional predictions of cellular processes, such as gene-regulatory networks were stored. Principal institution: Department of Life Sciences (FLW), TU Braunschweig. All known metabolic reactions are depicted here for the ‘Urea cycle and metabolism of amino groups’ pathway. Street: Langer Kamp 8: Zip-Code: 38106: City: Braunschweig: Website: Long Description: The institute of joining and welding of the Technical University of Braunschweig has approximately 60 employees, 35 thereof being scientific staff. For this purpose, a major portion of the data of SYSTOMONAS, such as KEGG compounds, reactions or PRODORIC transcription factor—gene interactions is locally stored. the prediction of the regulation of certain genes by specific transcription factors. Besides the medically relevant P.aeruginosa the genera Pseudomonas contains various important plant pathogens and biotechnologically as well as ecologically interesting species. Phone: +49 (0) 531 391-0 Chromatin structure restricts origin utilization when quiescent cells re-enter the cell cycle, NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis, The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration, Chemical Biology and Nucleic Acid Chemistry, Gene Regulation, Chromatin and Epigenetics, COMPARATIVE GENOMICS AND REGULATORY NETWORK PREDICTION, Receive exclusive offers and updates from Oxford Academic, M1CR0B1AL1Z3R—a user-friendly web server for the analysis of large-scale microbial genomics data, Prokaryotic Virus Orthologous Groups (pVOGs): a resource for comparative genomics and protein family annotation, SUPFAM—a database of potential protein superfamily relationships derived by comparing sequence-based and structure-based families: implications for structural genomics and function annotation in genomes. E-mail address: h.waetzig@tu‐ Technische Universität Braunschweig, Institut für Pharmazeutische Chemie, Braunschweig, Germany. Conflict of interest statement. Institut für Finanzwirtschaft, Technische Universität Braunschweig Collections in this community. Leibniz Universität Hannover. … Dear students and all interested parties, we are re-designing our website and want to include you in the process. Institut für Pharmazeutische Wissenschaften, Pharmazeutische Biologie und Biotechnologie, Albert-Ludwigs-Universität Freiburg, Stefan-Meier-Str. KEGG provided metabolic reactions, compounds, glycans and pathways; PGDv2 and PRODORIC supplied protein, gene annotation, gene-regulatory and genome structure data. Metabolites were analysed by GC/MS. The metabolite name for every data point is shown as tooltip while moving the mouse over the point (e.g. Traditionally, metabolic and gene-regulatory networks were analysed separately. 1. Telefon +49-(0)531-391-5800 Telefax +49-(0)531-391-5854. Institut für Medizinische Mikrobiologie und Krankenhaushygiene. nat. This tool does not only display multiple alignments but is also able to generate a phylogenetic tree for the protein group by different algorithms. Biozentrum Spielmannstraße 7 38106 Braunschweig, Telefon +49-(0)531-391-5800 Telefax +49-(0)531-391-5854, Braunschweiger Zentrum für Systembiologie (BRICS) Rebenring 56 38106 Braunschweig, Stellen der TU Braunschweig Jobbörse des Career Service Merchandising Sponsoring- & Spendenleistungen Drittmittelgeförderte Forschungsprojekte, Semestertermine Lehrveranstaltungen Studiengänge von A-Z Informationen für Erstsemester TUCard, Status GITZ-Dienste Handbuch für TYPO3 (Intern) Corporate Design-Toolbox (Intern) Glossar (DE-EN) Meine Daten ändern Hochschulöffentliche Bekanntmachungen, Technische Universität Braunschweig Universitätsplatz 2 38106 Braunschweig Postfach: 38092 Braunschweig Telefon: +49 (0) 531 391-0. Informationen zu den dort erfassten Daten und deren Verarbeitung finden Sie in deren Datenschutzerklärung. Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany . This organism is a versatile soil bacterium and an important opportunistic pathogen causing persistent infection in immunocompromised patients (12). 2 Technische Universität Braunschweig, Institut für Mikrobiologie, Braunschweig, Germany Helmholtz Centre for Infection Research, Braunschweig, Germany Herzlich mit vielen Willkommens-Mails wurde Professor Dan Schürch im Department Architektur Technische Universität Braunschweig empfangen. Our raw data analysed by GC/MS can be accessed via the query form ‘omics data’. Institut für Konstruktionstechnik - - - 1 Server: LSF19 Imprint and privacy Accessibility Statement QIS and LSF are products of eG Susanne ERNST of Technische Universität Braunschweig, Braunschweig | Read 10 publications | Contact Susanne ERNST By comparison, PseudoCyc contains 738 enzymes (version 9.6, Author Webpage). suchen. If the metabolic profile during one experimental condition is similar to the condition compared, data points will arrange closely to the diagonal line. (1–3)], and for the generation of gene-regulatory networks (4), i.e. Angestellt, Werkstudentin am Institut für Marketing, Technische Universität Braunschweig. for the data point ‘Lactate’) and linked back to the corresponding database entry. Deutsches Institut für Erwachsenenbildung, Leibniz-Zentrum für Lebenslanges Lernen Bonn IZA Institute of Labor Economics Forschungsinstitut zur Zukunft der Arbeit GmbH (IZA) Bonn University of Bonn Rheinische Friedrich-Wilhelms-Universität Bonn Braunschweig Technische Universtität Braunschweig Technische Universtität Braunschweig Despite this importance, the molecular mechanisms mediating this process are only poorly understood in biological systems. We provide SBML (27) formatted files for downloading our metabolic and gene-regulatory networks along with a database copy at the SYSTOMONAS website. However, all current information coming from genomics, transcriptomics and proteomics (13) is also stored in our database as data warehouse (14) or dynamically accessible via web services using SOAP interfaces (15), a platform-independent data transfer protocol (see section ‘Database Techniques’). Second, homology analyses lead to putative orthologous protein pairs (see section ‘Comparative Genomics’). If the levels of specific metabolites differ significantly between different conditions, the measured values are found distinct to a fictive diagonal line. COVID-19 is a severe acute respiratory disease caused by SARS-CoV-2, a novel betacoronavirus discovered in December 2019 and closely related to the SARS coronavirus (CoV). A metabolic network including all involved enzymes, metabolic reactions and metabolites of all pseudomonads is delivered by our own adapted tool, which is based on GraphViz (22) and creates clickable image maps (Figure 1). It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Working Paper Series, Institut für Finanzwirtschaft, TU Braunschweig Institut für Hygiene und Mikrobiologie Josef-Schneider-Straße 2 97080 Würzburg Suche … First, a restricted BLAST analysis (18) was performed on the protein sequences followed by a pairwise global alignment using the tool stretcher of the EMBOSS package (19). P. O. Medizinische Hochschule Hannover. 031U110A/031U210A) and the Volkswagen Foundation. All newly detected EC numbers by metaSHARK are also indicated as ‘predicted’ in SYSTOMONAS. Box: 38092 Braunschweig GERMANY. Search for more papers by this … The 1509 annotated enzymes were retrieved from KEGG (1003), PGDv2 (1017), BioCyc (493), ENZYME (393) and from our own annotation (241). The enzyme designation of proteins was determined in three steps. OK Abbrechen. The web server is Apache 2.0 (Author Webpage). If the user is interested in the prediction of transcription factor binding sites and the deduction of corresponding regulons the tool Virtual Footprint (4) can be employed. These services complement a specific record of the indicated SYSTOMONAS website form by transferring the appropriate information from the given external database. Mit 'OK' verlassen Sie die Seiten der Universität Würzburg und werden zu Twitter weitergeleitet. Logg Dich jetzt ein, um das ganze Profil zu sehen. Institut für Zellbiologie und Biophysik. Seit dem Beginn des Sommersemesters leitet der Schweizer Architekt das Institut für Entwerfen und Baugestaltung (IEB) ­– aus der Distanz, am 1. Effect of Cryptotanshinone on Measures of Rat Cardiomyocyte Oxidative Stress and Gene Activation Associated with Apoptosis. Search for other works by this author on: Institut für Biochemie, Universität zu Köln, Zülpicher Straße 47, D-50674 Köln, Germany, Fachbereich Informatik, Fachhochschule Wolfenbüttel, Institut für Bioverfahrenstechnik, Technische Universität Braunschweig, Gaußstraße 17, D-38106 Braunschweig, Germany, metaSHARK: software for automated metabolic network prediction from DNA sequence and its application to the genomes of, PathFinder: reconstruction and dynamic visualization of metabolic pathways, Virtual Footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes, Expansion of the BioCyc collection of pathway/genome databases to 160 genomes, PRODORIC: prokaryotic database of gene regulation, BRENDA, the enzyme database: updates and major new developments, From genomics to chemical genomics: new developments in KEGG, The University of Minnesota Biocatalysis/Biodegradation Database: the first decade, BLAST: at the core of a powerful and diverse set of sequence analysis tools, EMBOSS: the European Molecular Biology Open Software Suite, MUSCLE: multiple sequence alignment with high accuracy and high throughput, An open graph visualization system and its applications to software engineering, DDBJ in preparation for overview of research activities behind data submissions, EMBL Nucleotide Sequence Database: developments in 2005, Atlas–a data warehouse for integrative bioinformatics, Systems biology markup language: level 2 and beyond. Many thanks go to Mathias Krull and Barbara Schulz, who proof-read this paper. To develop neutralizing anti-SARS-CoV-2 antibodies, antibody gene libraries from convalescent COVID-19 … Herzlich Willkommen auf der offiziellen Facebook-Seite der TU Clausthal! ENZYME (17) and BioCyc (5) provide further functional characterization of proteins. We have chosen the open source object-relational database management system PostgreSQL 8.0.3 (Author Webpage) for our database. Medizinische Hochschule Hannover. 28.09.2020 Schwarzen Flecken in der Kartoffel auf der Spur. Several databases provide web services via SOAP, such as the major sequence databases (23–25). Further enzymes were annotated by comparative genomics (column ‘Predicted’), which were missing in the databases mentioned afore. Search for more papers by this author. Institutskolloquium am 26.01.206, Institut für Landschaftsbiogeochemie, Leibniz-Zentrum für Agrarlandschaftsforschung (ZALF) e. V. 2015 Anaerobic food chain as driver of biohydrogen and methane production from complex organic matter. Table 1 lists parts of the corresponding database content. The database structure of SYSTOMONAS is suitable for the simple storage of various types of experimental data. Hartmut Fricke: Technische … Institut für Mikrobiologie. Third, if the identity of the global alignment (stretcher) equals or exceeds 60%, all EC number connections to proteins were transferred to their orthologous protein partners. Currently, the data of SYSTOMONAS along with its visualization tools and web services can be accessed freely via a web-based user interface (Author Webpage). Recombinant human antibodies are proven potent neutralizers of viruses and can block the interaction of viral surface proteins with their host receptors. The basis of our approach is SYSTOMONAS, a comprehensive database that includes data from all levels of analysis as microarray and proteomics data, metabolite measurements, sequence data, gene-regulatory networks and corresponding enzyme data.

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